High prevalence of TP53 loss and whole-genome doubling in early-onset colorectal cancer

The global incidence of early-onset colorectal cancer (EO-CRC) is rapidly rising. However, the reason for this rise in incidence as well as the genomic characteristics of EO-CRC remain largely unknown. We performed whole-exome sequencing in 47 cases of EO-CRC and targeted deep sequencing in 833 case...

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Bibliographic Details
Published in:Exp Mol Med
Main Authors: Kim, Jeong Eun, Choi, Jaeyong, Sung, Chang-Ohk, Hong, Yong Sang, Kim, Sun Young, Lee, Hyunjung, Kim, Tae Won, Kim, Jong-Il
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080557/
https://ncbi.nlm.nih.gov/pubmed/33753878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-021-00583-1
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