Transcriptional firing represses bactericidal activity in cystic fibrosis airway neutrophils

Neutrophils are often considered terminally differentiated and poised for bacterial killing. In chronic diseases such as cystic fibrosis (CF), an unexplained paradox pits massive neutrophil presence against prolonged bacterial infections. Here, we show that neutrophils recruited to CF airways in viv...

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Veröffentlicht in:Cell Rep Med
Hauptverfasser: Margaroli, Camilla, Moncada-Giraldo, Diego, Gulick, Dalia Arafat, Dobosh, Brian, Giacalone, Vincent D., Forrest, Osric A., Sun, Fangxu, Gu, Chunhui, Gaggar, Amit, Kissick, Haydn, Wu, Ronghu, Gibson, Greg, Tirouvanziam, Rabindra
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080108/
https://ncbi.nlm.nih.gov/pubmed/33948572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2021.100239
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