Transcriptional firing represses bactericidal activity in cystic fibrosis airway neutrophils

Neutrophils are often considered terminally differentiated and poised for bacterial killing. In chronic diseases such as cystic fibrosis (CF), an unexplained paradox pits massive neutrophil presence against prolonged bacterial infections. Here, we show that neutrophils recruited to CF airways in viv...

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Gepubliceerd in:Cell Rep Med
Hoofdauteurs: Margaroli, Camilla, Moncada-Giraldo, Diego, Gulick, Dalia Arafat, Dobosh, Brian, Giacalone, Vincent D., Forrest, Osric A., Sun, Fangxu, Gu, Chunhui, Gaggar, Amit, Kissick, Haydn, Wu, Ronghu, Gibson, Greg, Tirouvanziam, Rabindra
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080108/
https://ncbi.nlm.nih.gov/pubmed/33948572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2021.100239
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