Dehydrocostus Lactone Attenuates the Senescence of Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration via Inhibition of STING-TBK1/NF-κB and MAPK Signaling

The progression of intervertebral disc degeneration (IDD) is multifactorial with the senescence of nucleus pulposus (NP) cells and closely related to inflammation in NP cells. Dehydrocostus lactone (DHE) is a natural sesquiterpene lactone isolated from medicinal plants that has anti-inflammatory pro...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Pharmacol
Egile Nagusiak: Chen, Zhiqian, Yang, Xiao, Zhou, Yifan, Liang, Zhihao, Chen, Chen, Han, Chen, Cao, Xiankun, He, Wenxin, Zhang, Kai, Qin, An, Zhou, Tangjun, Zhao, Jie
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2021
Gaiak:
Pharmacology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079987/
https://ncbi.nlm.nih.gov/pubmed/33935734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.641098
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