The Mechanism of Action of Antigen Processing Independent T Cell Epitopes Designed for Immunotherapy of Autoimmune Diseases

Immunotherapy with antigen-processing independent T cell epitopes (apitopes) targeting autoreactive CD4(+) T cells has translated to the clinic and been shown to modulate progression of both Graves’ disease and multiple sclerosis. The model apitope (Ac1-9[4Y]) renders antigen-specific T cells anergi...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: Shepard, Ella R., Wegner, Anja, Hill, Elaine V., Burton, Bronwen R., Aerts, Sarah, Schurgers, Evelien, Hoedemaekers, Brecht, Ng, Sky T. H., Streeter, Heather B., Jansson, Lotta, Wraith, David C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079784/
https://ncbi.nlm.nih.gov/pubmed/33936079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.654201
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