Phospho-Site Mutations in Transcription Factor Suppressor of Hairless Impact Notch Signaling Activity During Hematopoiesis in Drosophila

The highly conserved Notch signaling pathway controls a multitude of developmental processes including hematopoiesis. Here, we provide evidence for a novel mechanism of tissue-specific Notch regulation involving phosphorylation of CSL transcription factors within the DNA-binding domain. Earlier we f...

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Udgivet i:Front Cell Dev Biol
Main Authors: Frankenreiter, Lisa, Gahr, Bernd M., Schmid, Hannes, Zimmermann, Mirjam, Deichsel, Sebastian, Hoffmeister, Philipp, Turkiewicz, Aleksandra, Borggrefe, Tilman, Oswald, Franz, Nagel, Anja C.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079769/
https://ncbi.nlm.nih.gov/pubmed/33937259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.658820
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