Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A

Werner syndrome (WRN) is a rare progressive genetic disorder, caused by functional defects in WRN protein and RecQ4L DNA helicase. Acceleration of the aging process is initiated at puberty and the expected life span is approximately the late 50 s. However, a Wrn-deficient mouse model does not show p...

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Vydáno v:Sci Rep
Hlavní autoři: Kang, So-mi, Yoon, Min-Ho, Lee, Su-Jin, Ahn, Jinsook, Yi, Sang Ah, Nam, Ki Hong, Park, Soyoung, Woo, Tae-Gyun, Cho, Jung-Hyun, Lee, Jaecheol, Ha, Nam-Chul, Park, Bum-Joon
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079706/
https://ncbi.nlm.nih.gov/pubmed/33907225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88325-1
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