Expression of the SARS-CoV-2 receptorACE2 in human heart is associated with uncontrolled diabetes, obesity, and activation of the renin angiotensin system

BACKGROUND: Diabetic and obese patients are at higher risk of severe disease and cardiac injury in corona virus 2 (SARS-CoV-2) infections. Cellular entry of SARS-CoV-2 is mainly via the angiotensin-converting enzyme 2 (ACE2) receptor, which is highly expressed in normal hearts. There is a disagreeme...

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Bibliographic Details
Published in:Cardiovasc Diabetol
Main Authors: Herman-Edelstein, Michal, Guetta, Tali, Barnea, Amir, Waldman, Maayan, Ben-Dor, Naomi, Barak, Yaron, Kornowski, Ran, Arad, Michael, Hochhauser, Edith, Aravot, Dan
Format: Artigo
Language:Inglês
Published: BioMed Central 2021
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Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8078096/
https://ncbi.nlm.nih.gov/pubmed/33906662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-021-01275-w
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