Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107

BACKGROUND: The α7 nicotinic acetylcholine receptor (α7 nAChR) negatively regulates the synthesis and release of pro-inflammatory cytokines by immune cells. Our previous studies showed that in encephalitogenic T cells, α7 nAChR expression is upregulated and that activation of the cholinergic system...

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Publicado en:J Neuroinflammation
Autores principales: Mizrachi, Tehila, Marsha, Oshrit, Brusin, Karen, Ben-David, Yael, Thakur, Ganesh A., Vaknin-Dembinsky, Adi, Treinin, Millet, Brenner, Talma
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8077754/
https://ncbi.nlm.nih.gov/pubmed/33902624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02149-4
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