A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression

Objective: C49 is a chalcone derivative. The aim of the current study is to illuminate the efficacy of C49 in reversing multidrug resistance (MDR) in MCF-7/DOX cells and its underlying molecular mechanism. Methods: The cytotoxic effects of C49 on MCF-7/DOX cells were evaluated by MTT assay using dif...

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Vydáno v:Front Pharmacol
Hlavní autoři: Wang, Ting, Dong, Jingjing, Yuan, Xu, Wen, Haotian, Wu, Linguangjin, Liu, Jianwen, Sui, Hua, Deng, Wanli
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8076869/
https://ncbi.nlm.nih.gov/pubmed/33927626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.653306
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