Frequent post-operative monitoring of colorectal cancer using individualised ctDNA validated by multiregional molecular profiling

BACKGROUND: Circulating tumour DNA (ctDNA) is known as a tumour-specific personalised biomarker, but the mutation-selection criteria from heterogeneous tumours remain a challenge. METHODS: We conducted multiregional sequencing of 42 specimens from 14 colorectal tumours of 12 patients, including two...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Yaegashi, Mizunori, Iwaya, Takeshi, Sasaki, Noriyuki, Fujita, Masashi, Ju, Zhenlin, Siwak, Doris, Hachiya, Tsuyoshi, Sato, Kei, Endo, Fumitaka, Kimura, Toshimoto, Otsuka, Koki, Sugimoto, Ryo, Sugai, Tamotsu, Liotta, Lance, Lu, Yiling, Mills, Gordon B., Nakagawa, Hidewaki, Nishizuka, Satoshi S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8076308/
https://ncbi.nlm.nih.gov/pubmed/33658639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-021-01266-4
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