Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture

Effective control of COVID-19 requires antivirals directed against SARS-CoV-2. We assessed 10 hepatitis C virus (HCV) protease-inhibitor drugs as potential SARS-CoV-2 antivirals. There is a striking structural similarity of the substrate binding clefts of SARS-CoV-2 main protease (M(pro)) and HCV NS...

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Publicado no:Cell Rep
Main Authors: Bafna, Khushboo, White, Kris, Harish, Balasubramanian, Rosales, Romel, Ramelot, Theresa A., Acton, Thomas B., Moreno, Elena, Kehrer, Thomas, Miorin, Lisa, Royer, Catherine A., García-Sastre, Adolfo, Krug, Robert M., Montelione, Gaetano T.
Formato: Artigo
Idioma:Inglês
Publicado em: The Author(s). 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8075848/
https://ncbi.nlm.nih.gov/pubmed/33984267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109133
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