Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir

[Image: see text] The outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global threat to human health. Using a multidisciplinary approach, we identified and validated the hepatitis C virus (HCV) protease inhibitor simepr...

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Bibliografiske detaljer
Udgivet i:ACS Cent Sci
Main Authors: Lo, Ho Sing, Hui, Kenrie Pui Yan, Lai, Hei-Ming, He, Xu, Khan, Khadija Shahed, Kaur, Simranjeet, Huang, Junzhe, Li, Zhongqi, Chan, Anthony K. N., Cheung, Hayley Hei-Yin, Ng, Ka-Chun, Ho, John Chi Wang, Chen, Yu Wai, Ma, Bowen, Cheung, Peter Man-Hin, Shin, Donghyuk, Wang, Kaidao, Lee, Meng-Hsuan, Selisko, Barbara, Eydoux, Cecilia, Guillemot, Jean-Claude, Canard, Bruno, Wu, Kuen-Phon, Liang, Po-Huang, Dikic, Ivan, Zuo, Zhong, Chan, Francis K. L., Hui, David S. C., Mok, Vincent C. T., Wong, Kam-Bo, Mok, Chris Ka Pun, Ko, Ho, Aik, Wei Shen, Chan, Michael Chi Wai, Ng, Wai-Lung
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2021
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8056950/
https://ncbi.nlm.nih.gov/pubmed/34075346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c01186
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