DUX-miR-344-ZMYM2-mediated activation of MERVL LTRs induces a totipotent 2C-like state

Mouse embryonic stem cells (ESCs) sporadically express preimplantation two-cell-stage (2C) transcripts, including MERVL endogenous retrovirus and Zscan4 cluster genes. Such 2C-like cells (2CLCs) can contribute to both embryonic and extraembryonic tissues when reintroduced into early embryos, althoug...

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Bibliografiske detaljer
Udgivet i:Cell Stem Cell
Main Authors: Yang, Fan, Huang, Xin, Zang, Ruge, Chen, Jiayu, Fidalgo, Miguel, Sanchez-Priego, Carlos, Yang, Jihong, Caichen, Alexander, Ma, Fanglin, Macfarlan, Todd, Wang, Huayan, Gao, Shaorong, Zhou, Hongwei, Wang, Jianlong
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8074926/
https://ncbi.nlm.nih.gov/pubmed/32032525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.01.004
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