The Targeting of MRE11 or RAD51 Sensitizes Colorectal Cancer Stem Cells to CHK1 Inhibition

SIMPLE SUMMARY: The ATR-CHK1 axis of the DNA damage response is crucial for the survival of most colorectal cancer stem cells (CRC-SCs), but a significant fraction of primary CRC-SCs either is resistant to ATR or CHK1 inhibitors or survives the abrogation of the ATR-CHK1 cascade despite an initial r...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Mattiello, Luca, Soliman Abdel Rehim, Sara, Musella, Martina, Sistigu, Antonella, Guarracino, Andrea, Vitale, Sara, Corradi, Francesca, Galassi, Claudia, Sperati, Francesca, Manic, Gwenola, De Maria, Ruggero, Vitale, Ilio
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8073980/
https://ncbi.nlm.nih.gov/pubmed/33921638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13081957
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