Profiling of Adipose and Skeletal Muscle in Human Pancreatic Cancer Cachexia Reveals Distinct Gene Profiles with Convergent Pathways

SIMPLE SUMMARY: More than 80% of patients with pancreatic ductal adenocarcinoma (PDAC) suffer cachexia, characterized by loss of muscle and fat. However, most cachexia studies were predominantly focused on muscle. Our clinical study showed adipose tissue loss as a prognosticator in PDAC cachexia. Ou...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Narasimhan, Ashok, Zhong, Xiaoling, Au, Ernie P., Ceppa, Eugene P., Nakeeb, Atilla, House, Michael G., Zyromski, Nicholas J., Schmidt, C. Max, Schloss, Katheryn N. H., Schloss, Daniel E. I., Liu, Yunlong, Jiang, Guanglong, Hancock, Bradley A., Radovich, Milan, Kays, Joshua K., Shahda, Safi, Couch, Marion E., Koniaris, Leonidas G., Zimmers, Teresa A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8073275/
https://ncbi.nlm.nih.gov/pubmed/33923976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13081975
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