Profiling of Adipose and Skeletal Muscle in Human Pancreatic Cancer Cachexia Reveals Distinct Gene Profiles with Convergent Pathways

SIMPLE SUMMARY: More than 80% of patients with pancreatic ductal adenocarcinoma (PDAC) suffer cachexia, characterized by loss of muscle and fat. However, most cachexia studies were predominantly focused on muscle. Our clinical study showed adipose tissue loss as a prognosticator in PDAC cachexia. Ou...

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Dettagli Bibliografici
Pubblicato in:Cancers (Basel)
Autori principali: Narasimhan, Ashok, Zhong, Xiaoling, Au, Ernie P., Ceppa, Eugene P., Nakeeb, Atilla, House, Michael G., Zyromski, Nicholas J., Schmidt, C. Max, Schloss, Katheryn N. H., Schloss, Daniel E. I., Liu, Yunlong, Jiang, Guanglong, Hancock, Bradley A., Radovich, Milan, Kays, Joshua K., Shahda, Safi, Couch, Marion E., Koniaris, Leonidas G., Zimmers, Teresa A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8073275/
https://ncbi.nlm.nih.gov/pubmed/33923976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13081975
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