Differential and Overlapping Effects of Melatonin and Its Metabolites on Keratinocyte Function: Bioinformatics and Metabolic Analyses

We investigated the effects of melatonin and its selected metabolites, i.e., N(1)-Acetyl-N(2)-formyl-5-methoxykynurenamine (AFMK) and 6-hydroxymelatonin (6(OH)Mel), on cultured human epidermal keratinocytes (HEKs) to assess their homeostatic activities with potential therapeutic implications. RNAseq...

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Veröffentlicht in:Antioxidants (Basel)
Hauptverfasser: Stefan, Joanna, Kim, Tae-Kang, Schedel, Fiona, Janjetovic, Zorica, Crossman, David K., Steinbrink, Kerstin, Slominski, Radomir M., Zmijewski, Jaroslaw, Tulic, Meri K., Reiter, Russel J., Kleszczyński, Konrad, Slominski, Andrzej T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8073250/
https://ncbi.nlm.nih.gov/pubmed/33920561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox10040618
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