Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells

Indolic and kynuric pathways of skin melatonin metabolism were monitored by liquid chromatography mass spectrometry in human keratinocytes, melanocytes, dermal fibroblasts, and melanoma cells. Production of 6-hydroxymelatonin [6(OH)M], N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) and 5-methoxy...

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Bibliographic Details
Main Authors: Kim, Tae-Kang, Kleszczyński, Konrad, Janjetovic, Zorica, Sweatman, Trevor, Lin, Zongtao, Li, Wei, Reiter, Russel J., Fischer, Tobias W., Slominski, Andrzej T.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2013
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688757/
https://ncbi.nlm.nih.gov/pubmed/23620527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-224691
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