Characterization of Serotonin and N-acetylserotonin Systems in the Human Epidermis and Skin Cells

Tryptophan hydroxylase (TPH) activity was detected in cultured epidermal melanocytes and dermal fibroblasts with respective Km of 5.08 and 2.83 mM and Vmax of 80.5 and 108.0 µmol/min. Low but detectable TPH activity was also seen in cultured epidermal keratinocytes. Serotonin and/or its metabolite a...

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Detalhes bibliográficos
Publicado no:J Pineal Res
Main Authors: Slominski, Andrzej T., Kim, Tae-Kang, Kleszczyński, Konrad, Semak, Igor, Janjetovic, Zorica, Sweatman, Trevor, Skobowiat, Cezary, Steketee, Jeffery D., Lin, Zongtao, Postlethwaite, Arnold, Li, Wei, Reiter, Russel J., Tobin, Desmond J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007327/
https://ncbi.nlm.nih.gov/pubmed/31770455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jpi.12626
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