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Helicase-like functions in phosphate loop containing beta-alpha polypeptides

The P-loop Walker A motif underlies hundreds of essential enzyme families that bind nucleotide triphosphates (NTPs) and mediate phosphoryl transfer (P-loop NTPases), including the earliest DNA/RNA helicases, translocases, and recombinases. What were the primordial precursors of these enzymes? Could...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Vyas, Pratik, Trofimyuk, Olena, Longo, Liam M., Deshmukh, Fanindra Kumar, Sharon, Michal, Tawfik, Dan S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8072362/
https://ncbi.nlm.nih.gov/pubmed/33846247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016131118
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