An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications

We describe the development of OncoFAP, an ultra-high-affinity ligand of fibroblast activation protein (FAP) for targeting applications with pan-tumoral potential. OncoFAP binds to human FAP with affinity in the subnanomolar concentration range and cross-reacts with the murine isoform of the protein...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Millul, Jacopo, Bassi, Gabriele, Mock, Jacqueline, Elsayed, Abdullah, Pellegrino, Christian, Zana, Aureliano, Dakhel Plaza, Sheila, Nadal, Lisa, Gloger, Andreas, Schmidt, Eleonore, Biancofiore, Ilaria, Donckele, Etienne J., Samain, Florent, Neri, Dario, Cazzamalli, Samuele
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8072232/
https://ncbi.nlm.nih.gov/pubmed/33850024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2101852118
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