Attrition of X Chromosome Inactivation in Aged Hematopoietic Stem Cells

During X chromosome inactivation (XCI), the inactive X chromosome (Xi) is recruited to the nuclear lamina at the nuclear periphery. Beside X chromosome reactivation resulting in a highly penetrant aging-like hematopoietic malignancy, little is known about XCI in aged hematopoietic stem cells (HSCs)....

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Publicado en:Stem Cell Reports
Main Authors: Grigoryan, Ani, Pospiech, Johannes, Krämer, Stephen, Lipka, Daniel, Liehr, Thomas, Geiger, Hartmut, Kimura, Hiroshi, Mulaw, Medhanie A., Florian, Maria Carolina
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8072063/
https://ncbi.nlm.nih.gov/pubmed/33798450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2021.03.007
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