Relative oxygen extraction fraction (rOEF) MR imaging reveals higher hypoxia in human epidermal growth factor receptor (EGFR) amplified compared with non-amplified gliomas

PURPOSE: Epidermal growth factor receptor (EGFR) amplification promotes gliomagenesis and is linked to lack of oxygen within the tumor microenvironment. Using hypoxia-sensitive spin-and-gradient echo echo-planar imaging and perfusion MRI, we investigated the influence of EGFR amplification on tissue...

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Publicat a:Neuroradiology
Autors principals: Oughourlian, Talia C., Yao, Jingwen, Hagiwara, Akifumi, Nathanson, David A., Raymond, Catalina, Pope, Whitney B., Salamon, Noriko, Lai, Albert, Ji, Matthew, Nghiemphu, Phioanh L., Liau, Linda M., Cloughesy, Timothy F., Ellingson, Benjamin M.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8071834/
https://ncbi.nlm.nih.gov/pubmed/33106922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00234-020-02585-8
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