Inhibiting FAK–Paxillin Interaction Reduces Migration and Invadopodia-Mediated Matrix Degradation in Metastatic Melanoma Cells

SIMPLE SUMMARY: The focal adhesion kinase (FAK) is over-expressed in a variety of human tumors and is involved in many aspects of the metastatic process. This has led to the development of small inhibitors of FAK kinase function which are currently evaluated in clinical trials. We demonstrate here t...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Mousson, Antoine, Legrand, Marlène, Steffan, Tania, Vauchelles, Romain, Carl, Philippe, Gies, Jean-Pierre, Lehmann, Maxime, Zuber, Guy, De Mey, Jan, Dujardin, Denis, Sick, Emilie, Rondé, Philippe
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8070677/
https://ncbi.nlm.nih.gov/pubmed/33919725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13081871
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