COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins

COPD-derived fibroblasts have increased cellular senescence. Senescent cell accumulation can induce tissue dysfunction by their senescence-associated secretory phenotype (SASP). We aimed to determine the SASP of senescent fibroblasts and COPD-derived lung fibroblasts, including severe, early-onset (...

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Publicat a:Thorax
Autors principals: Woldhuis, Roy R, Heijink, Irene H, van den Berge, Maarten, Timens, Wim, Oliver, Brian G G, de Vries, Maaike, Brandsma, Corry-Anke
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 2021
Matèries:
Brief Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8070616/
https://ncbi.nlm.nih.gov/pubmed/33273021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2020-215114
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