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Thiosemicarbazide Derivatives Decrease the ATPase Activity of Staphylococcus aureus Topoisomerase IV, Inhibit Mycobacterial Growth, and Affect Replication in Mycobacterium smegmatis

Compounds targeting bacterial topoisomerases are of interest for the development of antibacterial agents. Our previous studies culminated in the synthesis and characterization of small-molecular weight thiosemicarbazides as the initial prototypes of a novel class of gyrase and topoisomerase IV inhib...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Kowalczyk, Aleksandra, Paneth, Agata, Trojanowski, Damian, Paneth, Piotr, Zakrzewska-Czerwińska, Jolanta, Stączek, Paweł
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8069432/
https://ncbi.nlm.nih.gov/pubmed/33918623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22083881
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