Amsacrine Derivatives Selectively Inhibit Mycobacterial Topoisomerase I (TopA), Impair M. smegmatis Growth and Disturb Chromosome Replication

Amsacrine, which inhibits eukaryotic type II topoisomerase via DNA intercalation and stabilization of the cleavable topoisomerase-DNA complex, promotes DNA damage and eventually cell death. Amsacrine has also been shown to inhibit structurally distinct bacterial type I topoisomerases (TopAs), includ...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Szafran, Marcin J., Kołodziej, Marta, Skut, Patrycja, Medapi, Brahmam, Domagała, Agnieszka, Trojanowski, Damian, Zakrzewska-Czerwińska, Jolanta, Sriram, Dharmarajan, Jakimowicz, Dagmara
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056748/
https://ncbi.nlm.nih.gov/pubmed/30065714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.01592
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