Inhibition of Autophagy at Different Stages by ATG5 Knockdown and Chloroquine Supplementation Enhances Consistent Human Disc Cellular Apoptosis and Senescence Induction rather than Extracellular Matrix Catabolism

The intervertebral disc is the largest avascular organ. Autophagy is an important cell survival mechanism by self-digestion and recycling damaged components under stress, primarily nutrient deprivation. Resident cells would utilize autophagy to cope with the harsh disc environment. Our objective was...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Int J Mol Sci
Egile Nagusiak: Ito, Masaaki, Yurube, Takashi, Kanda, Yutaro, Kakiuchi, Yuji, Takeoka, Yoshiki, Takada, Toru, Kuroda, Ryosuke, Kakutani, Kenichiro
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8069032/
https://ncbi.nlm.nih.gov/pubmed/33921398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22083965
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