The PKA-p38MAPK-NFAT5-Organic Osmolytes Pathway in Duchenne Muscular Dystrophy: From Essential Player in Osmotic Homeostasis, Inflammation and Skeletal Muscle Regeneration to Therapeutic Target

In Duchenne muscular dystrophy (DMD), the absence of dystrophin from the dystrophin-associated protein complex (DAPC) causes muscle membrane instability, which leads to myofiber necrosis, hampered regeneration, and chronic inflammation. The resulting disabled DAPC-associated cellular pathways have b...

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Detalles Bibliográficos
Publicado en:Biomedicines
Main Authors: Herbelet, Sandrine, Merckx, Caroline, De Paepe, Boel
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
Assuntos:
Review
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8066813/
https://ncbi.nlm.nih.gov/pubmed/33808305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines9040350
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