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Germline Mutations in Other Homologous Recombination Repair-Related Genes Than BRCA1/2: Predictive or Prognostic Factors?

The homologous recombination repair (HRR) pathway repairs double-strand DNA breaks, mostly by BRCA1 and BRCA2, although other proteins such as ATM, CHEK2, and PALB2 are also involved. BRCA1/2 germline mutations are targeted by PARP inhibitors. The aim of this commentary is to explore whether germlin...

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Detalhes bibliográficos
Publicado no:J Pers Med
Main Authors: Cortesi, Laura, Piombino, Claudia, Toss, Angela
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8066561/
https://ncbi.nlm.nih.gov/pubmed/33800556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jpm11040245
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