PHD3 loss promotes exercise capacity and fat oxidation in skeletal muscle

Rapid alterations in cellular metabolism allow tissues to maintain homeostasis during changes in energy availability. The central metabolic regulator acetyl-CoA carboxylase 2 (ACC2) is rapidly phosphorylated during cellular energy stress by AMP-activated protein kinase (AMPK) to relieve its suppress...

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Publicado no:Cell Metab
Main Authors: Yoon, Haejin, Spinelli, Jessica B., Zaganjor, Elma, Wong, Samantha J., German, Natalie J., Randall, Elizabeth C., Dean, Afsah, Clermont, Allen, Paulo, Joao A., Garcia, Daniel, Li, Hao, Rombold, Olivia, Agar, Nathalie Y. R., Goodyear, Laurie J., Shaw, Reuben J., Gygi, Steven P., Auwerx, Johan, Haigis, Marcia C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065255/
https://ncbi.nlm.nih.gov/pubmed/32663458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.06.017
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