Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD

To adapt to fluctuating protein folding loads in the endoplasmic reticulum (ER), the Hsp70 chaperone BiP is reversibly modified with adenosine monophosphate (AMP) by the ER-resident Fic-enzyme FICD/HYPE. The structural basis for BiP binding and AMPylation by FICD has remained elusive due to the tran...

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Udgivet i:Nat Commun
Main Authors: Fauser, Joel, Gulen, Burak, Pogenberg, Vivian, Pett, Christian, Pourjafar-Dehkordi, Danial, Krisp, Christoph, Höpfner, Dorothea, König, Gesa, Schlüter, Hartmut, Feige, Matthias J., Zacharias, Martin, Hedberg, Christian, Itzen, Aymelt
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065156/
https://ncbi.nlm.nih.gov/pubmed/33893288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22596-0
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