Protein products of nonstop mRNA disrupt nucleolar homeostasis

Stalled mRNA translation results in the production of incompletely synthesized proteins that are targeted for degradation by ribosome-associated quality control (RQC). Here we investigated the fate of defective proteins translated from stall-inducing, nonstop mRNA that escape ubiquitylation by the R...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Stress Chaperones
Prif Awduron: Davis, Zoe H., Mediani, Laura, Antoniani, Francesco, Vinet, Jonathan, Li, Shuangxi, Alberti, Simon, Lu, Bingwei, Holehouse, Alex S., Carra, Serena, Brandman, Onn
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Netherlands 2021
Pynciau:
Original Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065075/
https://ncbi.nlm.nih.gov/pubmed/33619693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-021-01200-w
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