PIK3CA somatic alterations in invasive breast cancers: different spectrum from Caucasians to Chinese detected by next generation sequencing

PURPOSE: Somatic alteration of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) is a crucial therapeutic target in breast cancer (BC) and PI3Kα-specific inhibitor Alpelisib has been used in clinics. This study investigates the PIK3CA alterations in Chinese and Caucasia...

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Detalhes bibliográficos
Publicado no:Breast Cancer
Main Authors: Jia, Minghan, Liao, Ning, Chen, Bo, Zhang, Guochun, Wang, Yulei, Li, Xuerui, Cao, Li, Mok, Hsiaopei, Ren, Chongyang, Li, Kai, Li, Cheukfai, Wen, Lingzhu, Lin, Jiali, Wei, Guangnan, Balch, Charles M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065000/
https://ncbi.nlm.nih.gov/pubmed/33386585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12282-020-01199-5
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