Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB(1) Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster

Introduction: In mammals, sn-1-diacylglycerol lipases (DAGL) generate 2-arachidonoylglycerol (2-AG) that, as the major endocannabinoid, modulates synaptic neurotransmission by acting on CB1 cannabinoid receptors (CB(1)R). Even though the insect genome codes for inaE, which is a DAGL ortholog (dDAGL)...

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Detalhes bibliográficos
Publicado no:Cannabis Cannabinoid Res
Main Authors: Tortoriello, Giuseppe, Beiersdorf, Johannes, Romani, Susana, Williams, Gareth, Cameron, Gary A., Mackie, Ken, Williams, Michael J., Di Marzo, Vincenzo, Keimpema, Erik, Doherty, Patrick, Harkany, Tibor
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2021
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8064960/
https://ncbi.nlm.nih.gov/pubmed/33912677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/can.2020.0010
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