Low efficacy of recombinant SV40 in Ugt1a1(-/-) mice with severe inherited hyperbilirubinemia

In contrast to AAV, Simian Virus 40 (rSV40) not inducing neutralizing antibodies (NAbs) allowing re-treatment seems a promising vector for neonatal treatment of inherited liver disorders. Several studies have reported efficacy of rSV40 in animal models for inherited liver diseases. In all studies th...

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Foilsithe in:PLoS One
Main Authors: Shi, Xiaoxia, Bortolussi, Giulia, Bloemendaal, Lysbeth ten, Duijst, Suzanne, Muro, Andrés F., Bosma, Piter J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2021
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8064607/
https://ncbi.nlm.nih.gov/pubmed/33891666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0250605
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