Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice

Persistent activation of the latent transcription factor STAT3 is observed in gastric tumor epithelial and immune cells and is associated with a poor patient prognosis. Although targeting STAT3-activating upstream kinases offers therapeutically viable targets with limited specificity, direct inhibit...

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Publicado no:Cancer Immunol Res
Main Authors: Poh, Ashleigh R., Dwyer, Amy R., Eissmann, Moritz F., Chand, Ashwini L., Baloyan, David, Boon, Louis, Murrey, Michael W., Whitehead, Lachlan, O'Brien, Megan, Lowell, Clifford A., Putoczki, Tracy L., Pixley, Fiona J., O'Donoghue, Robert J.J., Ernst, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8064588/
https://ncbi.nlm.nih.gov/pubmed/31992566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0623
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