New monoclonal antibodies that recognize an unglycosylated, conserved, extracellular region of CD44 in vitro and in vivo, and can block tumorigenesis

CD44 is a transmembrane glycoprotein that binds to hyaluronic acid, plays roles in a number of cellular processes and is expressed in a variety of cell types. It is up-regulated in stem cells and cancer. Anti-CD44 monoclonal antibodies affect cell motility and aggregation, and repress tumorigenesis...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lusche, Daniel F., Wessels, Deborah J., Reis, Ryan J., Forrest, Cristopher C., Thumann, Alexis R., Soll, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8064539/
https://ncbi.nlm.nih.gov/pubmed/33891595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0250175
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