Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer

Inhibition of autophagy, the major cellular recycling pathway in mammalian cells, is a promising strategy for the treatment of triple-negative breast cancer (TNBC). We previously reported SBI-0206965, a small molecule inhibitor of unc-51-like autophagy activating kinase 1 (ULK1), which is a key regu...

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Publicat a:J Med Chem
Autors principals: Ren, Huiyu, Bakas, Nicole A., Vamos, Mitchell, Chaikuad, Apirat, Limpert, Allison S., Wimer, Carina D., Brun, Sonja N., Lambert, Lester J., Tautz, Lutz, Celeridad, Maria, Sheffler, Douglas J., Knapp, Stefan, Shaw, Reuben J., Cosford, Nicholas D. P.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8064294/
https://ncbi.nlm.nih.gov/pubmed/33200929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00873
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