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Native Human Antibody to Shr Promotes Mice Survival After Intraperitoneal Challenge With Invasive Group A Streptococcus

BACKGROUND: A vaccine against group A Streptococcus (GAS) has been actively pursued for decades. The surface receptor Shr is vital in GAS heme uptake and provides an effective target for active and passive immunization. Here, we isolated human monoclonal antibodies (mAbs) against Shr and evaluated t...

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Bibliografiset tiedot
Julkaisussa:J Infect Dis
Päätekijät: Chatterjee, Nilanjana, Huang, Ya-Shu, Lyles, Kristin V, Morgan, Julie E, Kauvar, Lawrence M, Greer, Susanna F, Eichenbaum, Zehava
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8064040/
https://ncbi.nlm.nih.gov/pubmed/32845315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiaa540
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