Native Human Antibody to Shr Promotes Mice Survival After Intraperitoneal Challenge With Invasive Group A Streptococcus

BACKGROUND: A vaccine against group A Streptococcus (GAS) has been actively pursued for decades. The surface receptor Shr is vital in GAS heme uptake and provides an effective target for active and passive immunization. Here, we isolated human monoclonal antibodies (mAbs) against Shr and evaluated t...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Chatterjee, Nilanjana, Huang, Ya-Shu, Lyles, Kristin V, Morgan, Julie E, Kauvar, Lawrence M, Greer, Susanna F, Eichenbaum, Zehava
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8064040/
https://ncbi.nlm.nih.gov/pubmed/32845315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiaa540
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