Enhanced detection of expanded repeat mRNA foci with hybridization chain reaction

Transcribed nucleotide repeat expansions form detectable RNA foci in patient cells that contribute to disease pathogenesis. The most widely used method for detecting RNA foci, fluorescence in situ hybridization (FISH), is powerful but can suffer from issues related to signal above background. Here w...

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Bibliografske podrobnosti
izdano v:Acta Neuropathol Commun
Main Authors: Glineburg, M. Rebecca, Zhang, Yuan, Krans, Amy, Tank, Elizabeth M., Barmada, Sami J., Todd, Peter K.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8063431/
https://ncbi.nlm.nih.gov/pubmed/33892814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01169-8
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