Appropriate aglycone modification significantly expands the glycan substrate acceptability of α1,6-fucosyltransferase (FUT8)

The α1,6-fucosyltransferase, FUT8, is the sole enzyme catalyzing the core-fucosylation of N-glycoproteins in mammalian systems. Previous studies using free N-glycans as acceptor substrates indicated that a terminal β1,2-GlcNAc moiety on the Man-α1,3-Man arm of N-glycan substrates is required for eff...

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Dades bibliogràfiques
Publicat a:Biochem J
Autors principals: Zhang, Roushu, Yang, Qiang, Boruah, Bhargavi M, Zong, Guanghui, Li, Chao, Chapla, Digantkumar, Yang, Jeong-Yeh, Moremen, Kelley W, Wang, Lai-Xi
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062310/
https://ncbi.nlm.nih.gov/pubmed/33734311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20210138
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