Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2

The Hedgehog (Hh) signaling pathway plays a crucial role in normal embryonic development and adult tissue homeostasis. On the other end, dysregulated Hh signaling triggers a prolonged mitogenic response that may prompt abnormal cell proliferation, favoring tumorigenesis. Indeed, about 30% of medullo...

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Publicat a:Front Cell Dev Biol
Autors principals: Angrisani, Annapaola, Di Fiore, Annamaria, Di Trani, Claudia Augusta, Fonte, Simone, Petroni, Marialaura, Lospinoso Severini, Ludovica, Bordin, Fabio, Belloni, Laura, Ferretti, Elisabetta, Canettieri, Gianluca, Moretti, Marta, De Smaele, Enrico
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Cell and Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8060498/
https://ncbi.nlm.nih.gov/pubmed/33898425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.638508
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