Reproductive outcomes from maternal loss of Nlrp2 are not improved by IVF or embryo transfer consistent with oocyte-specific defect.

Nlrp2 encodes a protein of the oocyte subcortical maternal complex (SCMC), required for embryo development. We previously showed that loss of maternal Nlrp2 in mice causes subfertility, smaller litters with birth defects and growth abnormalities in offspring, indicating that Nlrp2 is a maternal effe...

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Gepubliceerd in:Reprod Sci
Hoofdauteurs: Arian, Sara, Rubin, Jessica, Chakchouk, Imen, Sharif, Momal, Mahadevan, Sangeetha K., Erfani, Hadi, Shelly, Katharine, Liao, Lan, Lorenzo, Isabel, Ramakrishnan, Rajesh, Van den Veyver, Ignatia B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8060370/
https://ncbi.nlm.nih.gov/pubmed/33090377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s43032-020-00360-x
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