Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila

Reduced activity of the insulin/IGF signalling network increases health during ageing in multiple species. Diverse and tissue-specific mechanisms drive the health improvement. Here, we performed tissue-specific transcriptional and proteomic profiling of long-lived Drosophila dilp2-3,5 mutants, and i...

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Vydáno v:eLife
Hlavní autoři: Tain, Luke Stephen, Sehlke, Robert, Meilenbrock, Ralf Leslie, Leech, Thomas, Paulitz, Jonathan, Chokkalingam, Manopriya, Nagaraj, Nagarjuna, Grönke, Sebastian, Fröhlich, Jenny, Atanassov, Ilian, Mann, Matthias, Beyer, Andreas, Partridge, Linda
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2021
Témata:
Chromosomes and Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8060030/
https://ncbi.nlm.nih.gov/pubmed/33879316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67275
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