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Iron enhances the binding rates and translational efficiency of iron responsive elements (IREs) mRNA with initiation factor eIF4F

Interaction of iron responsive elements (IRE) mRNA with the translational machinery is an early step critical in the initiation of protein synthesis. To investigate the binding specificity of IRE mRNA for eIF4F, kinetic rates for the eIF4F·IRE RNA interactions were determined and correlated with the...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Khan, Mateen A., Domashevskiy, Artem V.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059860/
https://ncbi.nlm.nih.gov/pubmed/33882101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0250374
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