Spatial clustering of CD68+ tumor associated macrophages with tumor cells is associated with worse overall survival in metastatic clear cell renal cell carcinoma

Immune infiltration is typically quantified using cellular density, not accounting for cellular clustering. Tumor-associated macrophages (TAM) activate oncogenic signaling through paracrine interactions with tumor cells, which may be better reflected by local cellular clustering than global density...

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Vydáno v:PLoS One
Hlavní autoři: Chakiryan, Nicholas H., Kimmel, Gregory J., Kim, Youngchul, Hajiran, Ali, Aydin, Ahmet M., Zemp, Logan, Katende, Esther, Nguyen, Jonathan, Lopez-Blanco, Neale, Chahoud, Jad, Spiess, Philippe E., Fournier, Michelle, Dhillon, Jasreman, Wang, Liang, Moran-Segura, Carlos, El-Kenawi, Asmaa, Mulé, James, Altrock, Philipp M., Manley, Brandon J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059840/
https://ncbi.nlm.nih.gov/pubmed/33882057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0245415
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