Spatial clustering of CD68+ tumor associated macrophages with tumor cells is associated with worse overall survival in metastatic clear cell renal cell carcinoma

Immune infiltration is typically quantified using cellular density, not accounting for cellular clustering. Tumor-associated macrophages (TAM) activate oncogenic signaling through paracrine interactions with tumor cells, which may be better reflected by local cellular clustering than global density...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Chakiryan, Nicholas H., Kimmel, Gregory J., Kim, Youngchul, Hajiran, Ali, Aydin, Ahmet M., Zemp, Logan, Katende, Esther, Nguyen, Jonathan, Lopez-Blanco, Neale, Chahoud, Jad, Spiess, Philippe E., Fournier, Michelle, Dhillon, Jasreman, Wang, Liang, Moran-Segura, Carlos, El-Kenawi, Asmaa, Mulé, James, Altrock, Philipp M., Manley, Brandon J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2021
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059840/
https://ncbi.nlm.nih.gov/pubmed/33882057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0245415
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