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Negative selection on complex traits limits phenotype prediction accuracy between populations

Phenotype prediction is a key goal for medical genetics. Unfortunately, most genome-wide association studies are done in European populations, which reduces the accuracy of predictions via polygenic scores in non-European populations. Here, we use population genetic models to show that human demogra...

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Detalhes bibliográficos
Publicado no:Am J Hum Genet
Main Authors: Durvasula, Arun, Lohmueller, Kirk E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059340/
https://ncbi.nlm.nih.gov/pubmed/33691092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2021.02.013
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